Synthesis of Thiophen Substitue 5,6-Dihydrobenzoquinazolin-2-amine Compounds


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Tuğcu F. T.

2nd International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2020), Gaziantep, Turkey, 7 - 09 October 2020, pp.1-4

  • Publication Type: Conference Paper / Full Text
  • City: Gaziantep
  • Country: Turkey
  • Page Numbers: pp.1-4

Abstract

Synthesis of Thiophen Substitue 5,6-Dihydrobenzoquinazolin-2-amine Compounds

 

F.Tülay TUĞCU

Yildiz Technical University, Faculty of Science, Department of Chemistry

The benzoquinazoline  ring is one of the most investigated scaffolds in medicinal chemistry. This group of compounds exhibits numerous pharmacological activities such as anti-inflammatory, antimicrobial, analgesic, diuretic, antihypertensive, antibiotic and antitumoral properties and many benzoquinazolines have been demonstrated to inhibit kinases by competing with ATP for the kinase active site.

Therefore, in this study, some new substituted benzoquinazoline derivatives which are considered that may possess biological activity have been obtained via one-pot multicomponent method by using substitute-thiophen carboxaldehydes, guanidine carbonate and 1-tetralone; and the structures of all these synthesized compounds have been clarified with spectral data.

 

Thanks for Yıldız Technical University Scientific Research Projects Coordination's support in this study. Project No: 2012-01-02-GEP05.

 

Synthesis of Thiophen Substitue 5,6-Dihydrobenzoquinazolin-2-amine Compounds

 

F.Tülay TUĞCU

Yildiz Technical University, Faculty of Science, Department of Chemistry

The benzoquinazoline  ring is one of the most investigated scaffolds in medicinal chemistry. This group of compounds exhibits numerous pharmacological activities such as anti-inflammatory, antimicrobial, analgesic, diuretic, antihypertensive, antibiotic and antitumoral properties and many benzoquinazolines have been demonstrated to inhibit kinases by competing with ATP for the kinase active site.

Therefore, in this study, some new substituted benzoquinazoline derivatives which are considered that may possess biological activity have been obtained via one-pot multicomponent method by using substitute-thiophen carboxaldehydes, guanidine carbonate and 1-tetralone; and the structures of all these synthesized compounds have been clarified with spectral data.

 

Thanks for Yıldız Technical University Scientific Research Projects Coordination's support in this study. Project No: 2012-01-02-GEP05.