Claisen type Condensation of Methyl Ketones with Carbimidothioates: A New Gateway for the Synthesis of beta-Enaminones

Swaroop T. R., Rangappa K. S., TORUN L.

CHEMISTRYSELECT, vol.6, no.2, pp.177-180, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1002/slct.202004295
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.177-180
  • Yıldız Technical University Affiliated: Yes

Abstract

Carbimidothioates are synthesized by the reaction of Grignard reagents or heteroaryl lithium compounds with arylisothiocyanates followed by treatment with methyl iodide. Further, application of these intermediates in the synthesis of beta-enaminones by their condensation with methyl ketones in the presence of sodium hydride in DMF is reported. This method offers a new gateway for the synthesis of beta-enaminones, which are important building blocks in synthetic organic chemistry.