SYNTHESIS OF NEW TANDOSPIRONE ANALOGUES CARRYING 1-(3-(TRIFLUOROMETHYL)PHENYL)PIPERAZINE


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GÜNKARA Ö. T., Sucu B. O., Guleli M., Ocal N.

SYNTHETIC COMMUNICATIONS, cilt.44, sa.11, ss.1619-1628, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/00397911.2013.865236
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1619-1628
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

New tandospirone analogues containing a 1-[3-(trifluoromethyl) phenyl] piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)(2). The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported.