Preparation and optimization of biodegradable self-assembled PCL-PEG-PCL nano-sized micelles for drug delivery systems

Kocabay O. G., İsmail O.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.70, sa.5, ss.328-337, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/00914037.2020.1713784
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.328-337
  • Anahtar Kelimeler: Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone), polymeric micelles, nano-precipitation method, biodegradable, self-assembly, TRIBLOCK COPOLYMER, GOLD NANOPARTICLES, IN-VITRO, RELEASE, DOXORUBICIN, BIODISTRIBUTION, EFFICIENCY
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Biodegradable polymeric micelles have potential therapeutic applications; nevertheless, preparing micelles of a specific diameter and uniform size distribution is a challenge. Micelles were formed from the copolymer of poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) and the effect of PCEC molecular weight, PCL/PEG ratio, solvent-water miscibility, solvent concentration on particle size, polydispersity index and zeta potential of micelles were also investigated. The average particle sizes of the PCEC micelles ranged between 225-959 and 232-1211 nm for micelles prepared with acetone and dimethylformamide, respectively. The encapsulation efficiency is 78.98%. These results indicate that PCEC micelles can be used as drug carriers in controlled delivery systems.