A new eudesmanolide from Tanacetum balsamita L. and biological activities of extracts

Servi H., Goren N., ŞEN A., Servi E. Y.

NATURAL PRODUCT RESEARCH, cilt.37, sa.8, ss.1338-1348, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 8
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/14786419.2021.2005594
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1338-1348
  • Anahtar Kelimeler: Tanacetum balsamita, sesquiterpene lactones, flavonoids, coumarin, steroid, biological activity, SESQUITERPENE LACTONES, ANTIOXIDANT ACTIVITY, ANTIMICROBIAL ACTIVITY, CHEMICAL-COMPOSITION, ESSENTIAL OIL, IN-VITRO, FLAVONOIDS, CONSTITUENTS, AGENTS, ETHER
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The ethyl acetate and methanol extracts from aerial parts of Tanacetum balsamita yielded a new derivative of 1-acetyl-erivanin, namely 1-acetyl-3-epi-erivanin (17), some known compounds, namely seventeen sesquiterpene lactones, five flavonoids, four coumarins, and a steroid. All extracts displayed antibacterial activity against test microorganisms except for Escherichia coli. The methanol (TBM) extract with an IC50 value of 0.180 mg/mL exhibited good antioxidant activity against DPPH radical while all extracts showed significant anti-inflammatory activity against lipoxygenase enzyme. The ethyl acetate (TBEA) extract presented moderate activity against alpha-glucosidase enzyme with an IC50 of 0.808 mg/mL. The highest total phenol content with 91.050 mg GAE/g extract was found in TBM. It is the first study on the isolation of secondary metabolites as well as 5-lipoxygenase and alpha-glucosidase inhibitory activity of T. balsamita growing in Turkey.