Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Yıldız Teknik Üniversitesi, Elektrik-Elektronik Fakültesi, Biyomedikal Mühendisliği, Türkiye
Tezin Onay Tarihi: 2024
Tezin Dili: Türkçe
Öğrenci: Kaan Selçukhan SAKMAK
Danışman: Osman Günay
Özet:
Liver tumors are examined in two groups, primary and metastatic, and the primary
treatment methods are resection. When liver tumors are examined, it is seen that the
most common liver tumor is hepatocellular carcinoma. The fact that resection
cannot be applied to all patients with liver cancer causes alternative methods to be
used in the treatment of the disease. One of these methods, the Y-90
Radioembolization method, is based on the principle of shrinking or destroying the
existing tumor by injecting Yttrium-90, which is used as a radionuclide in the
treatment of liver tumors and produces β radiation, through the hepatic arteries that
largely feed the liver tumor. In this study, a hepatopulmonary shunt model,
previously designed in 3D and in which radioembolization treatment, with a
hepatopulmonary shunt rate of 10%, can be easily simulated, was used as a
phantom. Two tumors, large and small, were simulated in the liver section of the
model used and Yttrium-90 was injected into this area. After the radionuclide
substance was kept in the relevant tumor cavities for 14 days, radiation dose
xi
measurements were made on the lung and liver with the help of
thermoluminescence dosimeters. As a result, the highest dose level to which the
lung was exposed was measured between 1.4091 Sv and 1.845 Sv, while the dose
to which the liver was exposed was measured as 19.79 Sv to 25.077 Sv. When the
half-life of the radionuclide used was evaluated, it showed that the dose levels
obtained at the end of the 14th day could be evaluated as the dose levels used in
current treatment methods, and although the injected radionuclide did not show a
homogeneous distribution, it gave information about the dose level to which the
surrounding tissues were exposed.