Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Yıldız Teknik Üniversitesi, Elektrik-Elektronik Fakültesi, Biyomedikal Mühendisliği, Türkiye
Tezin Onay Tarihi: 2024
Tezin Dili: İngilizce
Öğrenci: Burak KULA
Danışman: Osman Günay
Özet:
Healthcare professionals' diagnostic
abilities were improved by hybrid medical imaging modalities such as PET/CT and
PET/MRI, which combined anatomical and functional data into a single image.
Still, there are issues, particularly with spatial resolution, which is
important for accurate disease identification.
A custom-made phantom with ten holes is
designed using Solidworks and manufactured using additive manufacturing to
assess the spatial resolution of PET/CT and PET/MRI. These holes were strategically
positioned along the phantom's mid-line on the front surface. A plexiglass box
was designed to enclose the phantom and filled water. The phantom was loaded
with FDG-18. PET/CT and PET/MRI equipment were used for image acquisition,
which were then processed using Image J and MATLAB to determine the full width
at half maximum (FWHM) values.
The activity vs distance plots demonstrated
that PET/CT was initially unable to distinguish the first five sources.
Comparably, PET/MRI was unable to distinguish the first four sources. Moreover,
the examination of FWHM values for PET/CT showed that FWHM values up to the
sixth source were unsatisfactory and FWHM for the remaining sources were
acceptable. Additionally, a similar pattern was seen in PET/MRI, with relevant
FWHM values starting from the sixth source. These were showing enhanced
separation performance over certain ranges.
This study concludes by highlighting the
unique strengths and weaknesses of PET/CT and PET/MRI in identifying
radioactive sources in diagnostic nuclear medicine. The radioactivity vs
distance plots clearly demonstrated the difficulties that both modalities had
when they attempted to distinguish sources that were closely separated and
demonstrated that PET/MRI's performance in this regard was superior to
PET/CT's. However, at a certain distance, both molecular imaging methods
performed well, as seen by significant FWHM values starting at the sixth
source. These results underline how crucial it is to evaluate spatial
resolution and differentiating ability as they have a direct bearing on how
well complex biological structures may be diagnosed. The findings of this study
will help to improve patient care by directing future developments in nuclear
medicine and continuing to optimise imaging techniques.