Polystyrene-Coated Magnetite Nanoparticles Based Dispersive Micro-Solid Phase Extraction of Active Pharmaceutical Ingredients of Antidepressant Drugs and Determination by GC-MS

DALGIÇ BOZYİĞİT G., Zaman B. T., ÖZDEMİR O. K., Kilinc Y., Chormey D. S., ENGİN G., ...More

CHEMISTRYSELECT, vol.7, no.10, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 10
  • Publication Date: 2022
  • Doi Number: 10.1002/slct.202104435
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Keywords: Antidepressants, Dispersive micro-solid phase extraction, Matrix matching, Medical wastewater, Nanoparticles, Polymerization, LIQUID-LIQUID MICROEXTRACTION, TRICYCLIC ANTIDEPRESSANTS, WHOLE-BLOOD, GAS-CHROMATOGRAPHY, QUANTIFICATION, COMPOSITE, SAMPLES, PLASMA, URINE, MS/MS
  • Yıldız Technical University Affiliated: Yes


A dispersive micro-solid phase extraction (D-mu-SPE) method based on polystyrene coated magnetic nanoparticles (PS@MNPs) was used to preconcentrate the active ingredients of three antidepressant drugs from aqueous solution to be determined by gas chromatography mass spectrometry. Eight prominent parameters of the D-mu-SPE method were optimized univariately to boost the recovery and extraction efficiency of the analytes. The three analytes recorded very low detection limits between 0.40 and 0.60 ng/mL, and the dynamic range was broad with high linearity. Medical wastewater was selected as test sample to evaluate the method's applicability and accuracy, and the percent recovery results obtained ranged between 90 and 98 % for two different spike concentrations. The proximity of the recovery results to 100 % and the low standard deviations validated the developed method's accuracy and precision, respectively.