One of the environmental consequences of energy production to meet ever-increasing energy demands is the greenhouse gas effect. With the effect of greenhouse gas, the earth's temperatures are increasing day by day and as a result, events that affect both living and natural life occur. However, in addition to its negative effects, the melting ice with increasing temperatures has enabled the emergence of new energy sources and trade routes. With new routes, sea transportation costs and durations have decreased considerably. In our study, energy and exergy analyzes will be performed parametrically according to different fluid types and working conditions of the cooling system of a ship operating in the arctic line. In this context, the effects of different fluids and design conditions on coefficient of performance, second law efficiency, exergy destruction and other performance criteria will be shown. From the analyzes, it was concluded that different fluids were suitable for different purpose functions and inferences were made about the share of system elements in total exergy destruction.