Akademik Veri Yönetim Sistemi
AlgaEurope 2023, Praha, Çek Cumhuriyeti, 12 - 15 Aralık 2023, ss.422
Polar microalgae produce valuable bioactives and especially effective antioxidants as a metabolic adaptation mechanism to tolerate oxidative environmental circumstances. Flavonoids, which are polyphenolic compounds found in microalgae, have an ability of scavenging free radicals, regulating cellular metabolism and preventing oxidative stress–related diseases such as cancer. In this manner, utilizing flavonoids obtained from polar microalgae which have resistance to extreme stress conditions against cancer cells is expected to offer promising outcomes. In this study, extracts of Auxenochlorella pyrenoidosa Ozcimen.001 (CP) and Chlorella sorokiniana Egemen.002 (CS) isolated from Antarctic and Arctic regions and their encapsulated forms were investigated for their efficacy on A-549 and MCF-7 cell lines. It was found that, the flavonoid contents of the CP and CS microalgae extracts were 1.16 mg Q/g DE and 0.6 mg Q/g DE, respectively. Both extracts and nanoparticles loaded with polar microalgal extracts, which have size range between 156-294 nm, and with 85-92% encapsulation efficiency, exhibited anti-cancer activity against A-549 and MCF-7 cell lines. In comparison with A-549 cell line, CP and CS extracts in 100 µg/mL concentration showed better results by decreasing the cell viability of MCF7 to approximately 60% for 48 h. In conclusion, it has been determined that the longer the exposure time of cells with samples, the greater the decrease in cell viability was seen. In the direction of the data obtained from the study showed that polar microalgae have the potential to be evaluated as an anticarcinogenic agent in the pharmaceutical area.
KEYWORDS
Anti-cancer activity, electrospraying, flavonoid, nanoparticle, polar microalgae