SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND PHENOBARBITAL IN SUPPOSITORIES BY PARTIAL LEAST-SQUARES SPECTROPHOTOMETRIC CALIBRATION

BOZDOGAN A. E., KUNT G., ACAR A.

ANALYTICAL LETTERS, cilt.25, sa.11, ss.2051-2058, 1992 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 11
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1080/00032719208020074
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2051-2058
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of suppositories in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and phenobarbital in suppository preparations. The results show that these components in a molar ratio of about 61:1 in suppositories have been determined simultaneously with high precision.