Synthesis and Biological Evaluation of New 4-Thiazolidinone Derivatives as Carbonic Anhydrase Inhibitors

Genc H., Ceken B., Bilen C., Sackes Z., Gencer N., Arslan O.

LETTERS IN ORGANIC CHEMISTRY, vol.14, no.2, pp.80-85, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.2174/1570178614666161230121658
  • Journal Name: LETTERS IN ORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.80-85
  • Yıldız Technical University Affiliated: No

Abstract

Background: The catalytically active site of CA enzyme is Zn (II) bound hydroxide ion part which acts as a strong nucleophile (at neutral pH) on the CO2 molecule bound in a hydrophobic pocket nearby. We designed a series of thiazolidinone molecules which are able to approach the active side by way of hydrophobic part and may interact with the hydroxide and Zn (II) by ring opening of thiazolidinone.