Synthetic peptide vaccine for Foot-and- Mouth Disease: synthesis, characterization and immunogenicity

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MANSUROĞLU B., DERMAN S., Kizilbey K., Ates S. C., Akdeste Z. M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.45, sa.6, ss.859-868, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2020-0110
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.859-868
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Background: The conjugations of antigenic synthetic peptide sequences with carrier polymers have opened new possibilities for the treatment of diseases. In this study, 135-161 peptide sequence of VP1 capsid protein of Foot-and-Mouth Disease was cross-linked with P(VP-co-AA) copolymer by covalent conjugation using water-soluble carbodiimide at different ratio of components (gamma=5, 7, 9, 11, 15) for the first time in the literature.