Kinetic Analysis of the Amino Terminal End of Active Site Loop of Lactate Deyhdrogenase from Plasmodium Vivax

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MUTLU Ö., Turgut-Balik D.

BALKAN MEDICAL JOURNAL, vol.29, no.4, pp.364-369, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5152/balkanmedj.2012.047
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.364-369
  • Keywords: Lactate dehydrogenase, Plasmodium vivax, antimalarial drug, site-directed mutagenesis, kinetic analysis, DEHYDROGENASE GENE, FALCIPARUM, EXPRESSION, PARASITE, MALARIA, CLONING
  • Yıldız Technical University Affiliated: Yes

Abstract

Objective: In this study, kinetic analysis was performed to understand the functional importance of the amino terminal of the active site of previously mutated Plasmodium vivax Lactate Dehydrogenase enzyme by mimicking Toxoplasma gondii I, II, Eimeria acervulina and Eimeria tenella LDH's.