IDENTITY OF ACE2 AS A RESULT OF BIOINFORMATIC INVESTIGATIONS


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Aktaş E. , Özdemir Özgentürk N.

CUMHURIYET 6th INTERNATIONAL CONGRESS ON APPLIED SCIENCES, Ankara, Turkey, 23 April 2022, pp.2

  • Publication Type: Conference Paper / Summary Text
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.2

Abstract

It is known that the Angiotensin Converting Enzyme-2 (ACE-2) receptor plays a crucial role not only in the SARS-CoV-induced epidemic but also in some diseases( especially the upper respiratory tract). There are many studies in the literature on the interaction of ACE2 and SARS CoV's protein. However, comprehensive research has not been conducted on ACE2 protein by using bioinformatic tools. In this study, both the chemical and physical properties of ACE2 were obtained using bioinformatics tools. In line with the results obtained, it was determined that especially the G104 and L106 points may role effective in protecting the structure of the ACE-2 protein, play a critical role in the biological functioning of this protein, and play an essential role in determining the chemical-physical properties of this protein. More importantly, It was also found that the G104 and L108 regions were more prone to possible mutations or deletions than the other ACE-2 protein regions. Having a negative GRAVY value, one transmembrane helix, a significant molecular weight, a long-estimated half-life as well as most having unstable are results of G104 and L108 points mutations or deletions. It was not surprisingly found that LQQNGSSVLS, which belong to the ACE-2 protein, may play an active role in binding the spike protein of SARS-CoV based on docking scores. This study further detailed the properties of the ACE2 receptor, and this study aims to provide a different perspective both in the study of diseases caused by ACE2 and in the interaction of ACE2 with SARS CoV.