New water-soluble cationic indium (III) phthalocyanine bearing thioquinoline moiety; Synthesis, photophysical and photochemical studies with high singlet oxygen yield

Kutlu O. D., Avcil D., Erdoğmuş A.

MAIN GROUP CHEMISTRY, vol.18, no.2, pp.139-151, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.3233/mgc-180720
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.139-151
  • Yıldız Technical University Affiliated: Yes


The synthesis and characterization of (4) -tetra[2-thioquinoline] phthalocyaninato indium (III) (2) and quaternized (4)-tetra[2-thioquinoline] phthalocyaninato indium (III) (3), are described. Photochemical and photophysical properties of 2 and 3 in DMSO; and of 3 in water are also presented. A comparison between the photophysical and photochemical parameters of 2 and 3 showed that 2 is a better photosensitizer than 3. The quantum yield values of fluorescence (Phi(F)), and singlet oxygen formation (Phi(Delta)) for 2 are 0.012 and 0.74, respectively. These values are higher than those for 3, which exhibited the values 0.006 and 0.66, respectively. The values for 3 in aqueous solution are 0.002 and 0.17 (0.42 plus Triton X-100) respectively due to aggregation behavior in the solution, and these values suggest that indium phthalocyanine 2 and its water-soluble derivative 3 can find use as photosensitizer in the photodynamic therapy (PDT) of cancer.