Enhanced Singlet Oxygen Generation Through Novel Diaxial Silicon Phthalocyanine Sensitizer: Synergistic Effect of Light and Ultrasound


Erdoğmuş A., Yaşa Atmaca G.

3 rd International Symposium on Characterization (ISC´23), İstanbul, Turkey, 6 - 08 September 2023, pp.42

  • Publication Type: Conference Paper / Summary Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.42
  • Yıldız Technical University Affiliated: Yes

Abstract

Photodynamic therapy (PDT) is a therapeutic procedure that involves the application and activation of a photosensitizer by light with an appropriate wavelength [1]. Among these therapy strategies, sonodynamic therapy (SDT) has been extensively investigated for cancer treatment in clinical researches during the past several years [2]. The cytotoxicity of ultrasound coupled with a sensitizing substance is also evaluated in association with photodynamic therapy (SPDT) [3]. Although many photosensitizers exist, phthalocyanine derivatives are those most commonly used as cancer treatment[4]. In this study, to contribute to the development of SPDT, a promising sensitizer was synthesized, characterized, and its photophysico-chemical properties were analyzed. Afterwards, the singlet oxygen quantum yield of the sensitizer was calculated by both photochemical and sono-photochemical studies.