NATURE STRUCTURAL BIOLOGY, vol.3, no.11, pp.912-915, 1996 (SCI-Expanded)
Article / Letter
NATURE STRUCTURAL BIOLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Yıldız Technical University Affiliated:
The crystal structure of Plasmodium falciparum lactate dehydrogenase reveals a surprising shift in the position of the NADH cofactor that explains the unusual biochemical properties of this enzyme. There is also a distinctive surface cleft adjacent to the NADH binding pocket that forms an attractive target for inhibitor design.