Design of a System for Analyzing Cell Mechanics

Creative Commons License

Işik Y., Abdioğlu H. B.

Experiment, pp.1-3, 2024

  • Publication Type: Other Publication / Experiment
  • Publication Date: 2024
  • Page Numbers: pp.1-3
  • Yıldız Technical University Affiliated: Yes

Abstract

Abstract—Accurately measuring cell stiffness is challenging

due to the invasiveness of traditional methods like atomic

force microscopy (AFM) and optical stretching. We introduce

a non-invasive off-axis system using holographic imaging and

acoustic stimulation. This system features an off-axis Mach-

Zehnder interferometer and bulk acoustic waves to capture

cell mechanics. It employs high-resolution components to create

detailed interferograms and allows continuous imaging of cell

deformation. Unlike conventional techniques, our method pro-

vides high-throughput, label-free measurements while preserving

cell integrity. Polyacrylamide beads are tested for high precision,

highlighting the potential of the system in early cancer detection,

disease monitoring, and mechanobiological research.