PRODUCTION AND OPTIMIZATION METHOD OF SMART HYDROGELS BASED ON BIOCOMPATIBLE POLYMER FOR CONTROLLED INSULIN RELEASE

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Atıf İçin Kopyala

ÖZGÜNDÜZ H. İ., Kandilci H. G., ACARALI N., Sarac H.

SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI, cilt.34, sa.1, ss.115-122, 2016 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 34 Sayı: 1
• Basım Tarihi: 2016
• Dergi Adı: SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals
• Sayfa Sayıları: ss.115-122
• Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The aim of controlled insulin delivery study experiments is to produce the smart hydrogel to use insulin release for human body. Insulin entrapped p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragit L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker and new alternative ways were worked on to find and develop. Taguchi method was used and optimum synthesis conditions were determined. Insulin was entrapped into hydrogels as synthesis. After entrapped method, loading efficiency values were calculated. and the hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis.