Parkin level in plasma of ALS patients

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Günel A., Vural Korkut Ş., İdrisoğlu H. A., Çelik R.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Dublin, Ireland, 17 November 2021, pp.105 identifier identifier

  • Publication Type: Conference Paper / Full Text
  • Doi Number: 10.1080/21678421.2021.1985792
  • City: Dublin
  • Country: Ireland
  • Page Numbers: pp.105
  • Yıldız Technical University Affiliated: Yes

Abstract

Accumulation of misfolded and damaged pro-

teins are known to be associated with the pathogenesis of

many   neurodegenerative   diseases   such   as   Parkinson ’ s

Disease, Alzheimer Disease, ALS (1 – 4). Parkin, an E3 ubiquitin-

protein ligase, is an important component of ubiquitin-prote-

asome  system  (5).  It  is  known  that  Parkin  is  important  for

especially  genetic  Parkinsonism.  There  is  limited  study  on

Parkin for ALS disease.