Application of comparative sonochemical, photochemical, and sono-photochemical methods to obtain new silicon phthalocyanine with high singlet oxygen efficiency

Atmaca G. Y., Celep K., ERDOĞMUŞ A.

Journal of Organometallic Chemistry, vol.1004, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 1004
  • Publication Date: 2024
  • Doi Number: 10.1016/j.jorganchem.2023.122952
  • Journal Name: Journal of Organometallic Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
  • Keywords: Photosensitizer, Silicon phthalocyanine, Sono-photodynamic therapy, Synthesis
  • Yıldız Technical University Affiliated: Yes

Abstract

Nowadays, non-invasive and nontoxic therapy methods are preferred to treat diverse types of cancer. Sono-photodynamic therapy (SPDT) is one of these alternative methods, combining the properties of PDT (photodynamic therapy) and SDT (sonodynamic therapy) and resulting in a higher singlet oxygen generation. The efficiency of this method is increased by synthesizing a complex with enhanced photochemical properties to use as a sensitizer. Phthalocyanines, especially with added derivatives holding diamagnetic metals such as Si4+, are often compounds used in PDT studies owing to their efficient yields of singlet oxygen formation. In this study, 4‑hydroxy-7-methoxyquinoline silicon phthalocyanine was synthesized and its anti-cancer therapy effect rates were calculated and compared by photochemical and sono-photochemical methods in DMSO. This research will help the studies that aim to obtain high singlet oxygen efficiency in therapeutic methods.