Akademik Veri Yönetim Sistemi
6th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 11 - 13 Ekim 2023, ss.1489
Regenerative medicine aims to address disorders caused by infections, inflammation, traumatic injury, and
accidents by repairing tissue damage. The Mexican axolotl (Ambystoma mexicanum) serves as a main model
organism for regenerative medicine. These species can regenerate all their organs and tissues in the case of
injury or amputation without developing any sort of scar. In our study, we aim to unlock the mystery of this
organism's extraordinary ability to divide by working at in-silico and molecular levels. We used preliminary
bioassays to determine which of the proteins that constitute neural regeneration capabilities are more favorable.
We identified that the Wnt/ß-catenin signaling pathway is one of the most prominent pathways regulating
proliferation in Mexican axolotls and that the Wnt-1 is a major functional protein in this pathway.
Bioinformatics tools such as Phyre2, HDOCK, and DisEMBL have been used to comprehensively investigate
the components of the Wnt/ß-catenin signaling pathway synthesized from the apical epidermal cover and their
relationship with neural regeneration. Analyses have shown that interactions of Wnt-1 proteins with various
vitamins such as vitamin A, vitamin D, and vitamin E can affect this signaling pathway. In this respect, proteinvitamin binding complexes may be important not only in terms of docking scores but also in terms of their
effects on signaling pathways. In conclusion, with the increasing relevance of bioinformatics studies, it is
possible to understand the mechanism of regeneration more rapidly by developing studies at the molecular
level. We believe that our study will contribute to regenerative medicine studies and may provide a different
perspective on possible treatment methods.