In this paper, we presented a general kinetic analysis of the reversible enzymatic system for the case in which the substrate, the enzyme-substrate complex and the product are all unstable. Using computer algebra technique, we solve the system of ordinary differential equations symbolically under the assumption [E] >> [S]. Since this condition satisfied inside the cells, it can be more relevant to physiological problems. Then using numerical values, simulation progress curves for the concentration of all species are obtained. (C) 2000 Elsevier Science Inc. All rights reserved.