Due to population growth and global warming, the use of the sea water reverse osmosis process to obtain freshwater is increasing rapidly. A sustainable method with low environmental impact is limited for the management of brine with a high salt content, which is released as a result of the process. Some microalgae species can grow in salty environments and produce 0-carotene. This study aims to evaluate the commercial potential of 0-carotene production from microalgae grown in sea water reverse osmosis brine from a bioeconomy perspective. Synthetic media are often used for the production of 0-carotene from algae, the use of sea water reverse osmosis brine is not common and the commercial potential of this application has not been evaluated before. In terms of the development of the 0-carotene market, the strengths and weaknesses of the process, opportunities, and threats are thoroughly examined in this report. Also, with the use of sea water reverse osmosis, a daily 750 tons of algal 0-carotene can be produced. The biotechnological production of microalgal 0-carotene and the reuse of salt water within the scope of circular bioeconomy are seen as a sustainable solution due to the fact that the strengths of the process are dominant, and the market value of natural 0-carotene is increasing day by day.