A quality-effects model for meta-analysis

Doi S. A. R., Thalib L.

EPIDEMIOLOGY, cilt.19, sa.1, ss.94-100, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/ede.0b013e31815c24e7
  • Dergi Adı: EPIDEMIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.94-100
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

We introduce a quality-effects approach that combines evidence from a series of trials comparing 2 interventions. This approach incorporates the heterogeneity of effects in the analysis of the overall interventional efficacy. However, unlike the random-effects model based on observed between-trial heterogeneity, we suggest adjustment based on measured methodological heterogeneity between studies. We propose a simple noniterative procedure for computing the combined effect size under this model and suggest that this could represent a more convincing alternative to the random effects model.