In this paper, the investigation of thermodynamic performance of a hydrogen enriched wet-ethanol fuelled homogenous charge compression ignition (HCCI) engine is conducted through energy and exergy methods. The energy and exergy analyses are performed through a thermodynamic model by considering the gas composition formed after the combustion process. The energy and exergy efficiencies of the system increase from 41.56% to 44.01% and from 37.23% to 38.73%, respectively, with the increase in hydrogen energy share from 5% to 20% in the air-fuel mixture. The energy and exergy efficiencies of the system are found to be increasing with an increase in the pressure ratio of turbocharger and compressor polytropic efficiency. The increase in the ambient temperature results in the decrease in both energy and exergy efficiencies. The detailed exergy analysis of the system reveals that the highest exergy destruction is associated with HCCI engine, and the maximum available work increases with the increase in the hydrogen percentage.