Tough and hierarchical porous cryogel scaffolds preparation using n-butanol as a non-solvent


Sen T., Ozcelik B., Özmen M. M.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.68, pp.411-416, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 68
  • Publication Date: 2019
  • Doi Number: 10.1080/00914037.2018.1452225
  • Title of Journal : INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Page Numbers: pp.411-416

Abstract

Hierarchical porous chitosan cryogels were prepared by combination of cryogelation and phase separation techniques. n-Butanol was included as a non-solvent in the initial polymer solutions to enable phase separation. The internal morphology of the resulting cryogels revealed hierarchical porosity where larger pores of between 25-50 mu m were formed via cryogelation, whereas smaller pores of between 4-10 mu m were produced by phase separation. The control sample prepared without n-butanol exhibited monotype porosity. Any crack development was not observed when samples were compressed up to 80% strain. The results demonstrated hierarchical porous and tough scaffolds with potential use in tissue engineering.