CONSTRUCTION OF VASCULAR GRAFT BY 3D PRINTING USING BACTERIAL CELLULOSE FORMULATION AS BIOINK


Cesur N. P. , Lacin N. T.

CELLULOSE CHEMISTRY AND TECHNOLOGY, vol.56, no.1-2, pp.99-113, 2022 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 1-2
  • Publication Date: 2022
  • Title of Journal : CELLULOSE CHEMISTRY AND TECHNOLOGY
  • Page Numbers: pp.99-113
  • Keywords: 3D printing, patient-specific vascular graft, tissue engineering, NANOFIBER DENSITY, IN-SITU, CELL, TISSUE, SCAFFOLDS, POROSITY

Abstract

Currently, there is a considerable clinical demand for biocompatible and robust tissue-engineered artificial vascular graft materials. The vascular application requiring adequate mechanical strength and biocompatibility still lags at some critical points. Bacterial cellulose (BC) is well known for its use as a biomaterial in various fields due to its high biocompatibility. The most critical issue preventing the wide use of BC for 3D biomaterial printing is its insolubility in water and organic solvents. Because of this feature, the use of BC as bioink is limited. In this study, optimizing the solubility of BC with zinc sulphate, and the application of the obtained bioink with a 3D printing technique to create a model vascular graft, as well as examining it in terms of mechanical strength, were carried out for the first time in the literature.