Preparation of polyvinyl alcohol, chitosan and polyurethane-based pH-sensitive and biodegradable hydrogels for controlled drug release applications

Duru Kamaci Ü., Kamaci M.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.69, sa.18, ss.1167-1177, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 18
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/00914037.2019.1670180
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1167-1177
  • Anahtar Kelimeler: Antibacterial, biodegradable, chitosan, drug delivery, 5-fluoro uracil, NANOCOMPOSITE HYDROGELS, CELLULOSE NANOCRYSTALS, POLYMER, DELIVERY
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

In this study, novel hydrogels containing poly(azomethine-urethane) (PAMU), PVA and CS were prepared for controlled drug delivery application. FT-IR was used to confirm hydrogel structures. Thermal stability and mechanical behavior of the hydrogels were also investigated by using a thermogravimetric analysis (TG-DTA) and mechanical measurements. Swelling degree of the hydrogels were carried out at pH = 3, 7, and 12. Antibacterial properties of the hydrogels were also investigated using disc diffusion method. The obtained results showed that controlled drug release, swelling performance, and mechanical properties of the hydrogels were enhanced by increasing the amount of PAMU in the hydrogel matrix.