One-pot Multicomponent Reaction: An Efficient Synthesis of 4-(Het)Aryl-substituted Pyrazolo-quinolinones


BEKER H. K., KABAN Ş.

Current Organic Synthesis, vol.21, no.3, pp.292-297, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 3
  • Publication Date: 2024
  • Doi Number: 10.2174/1570179421666230821102745
  • Journal Name: Current Organic Synthesis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.292-297
  • Keywords: (het)aryl aldehyde, heterocyclic compound, multicomponent reaction, organic chemistry, pyrazolo[3,4-b]quinoline, Regiospecific pyrazole cyclo-condensation
  • Yıldız Technical University Affiliated: Yes

Abstract

Introduction: Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it was found that they have very advanced functionally promising as selective compounds due to their scaffold and demonstrated low toxicity and considerable clinical promise. Moreover, these compounds have an important role in different applications such as analytical reagents, technical, pharmaceutical development, and biological markers. So, we aimed to synthesize and characterize new 4-(Het)aryl-substituted Pyrazole-quinolinones. Methods: Synthesis of One-Pot Multicomponent Reaction was carried out with the reaction of 5-amino-3-methyl-1H-pyrazole 1a, and 5-amino-3-phenyl-1H-pyrazole 1b and dimedone 2 with some (het)aryl aldehydes 3 using ethanol. Characterizations such as the linear structures and the regiospecificity of the reactions were determined by using NMR, GC-MS, IR, and UV measurements. Results and Conclusion: This research will be very useful for all methods and procedures using multi one-point reactions which are very popular in the synthesis of heterocyclic systems for pyrazolequinoline skeleton synthesis.