Copyright © 2020 Inderscience Enterprises Ltd.Seaweed accumulation result in undesirable environmental problems along the coastline of Istanbul. In this study, methane production potential of seaweed/food waste matrix was evaluated to explore how much of waste seaweed could be fed with food waste to an anaerobic digester at what rates of substrate to inoculum (S/X). Results indicated that the reactors fed with only food waste were inhibited with the S/X ratio exceeding 4 g VSsubstrate/g VSinoculum, but it could be reached up to 2,172 m3biogas / m3reactor / d in continuous-fed-system when seaweed/food waste mixture ratio increases to 2/1 at 6 g VSsubstrate/g VSinoculum. This was indicated that seaweed was a useable agent with a good buffer capacity to improve performance of digesters arising from substrate inhibition. Methane production potential data was also modelled to describe the digestion kinetics by modified Gompertz, first-order, logistic function, and transference equation models. Transference function among applied models gave the best fit to describe the kinetics of methane production potential at practical applications.