Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones


Demir A., Hamamcı H., Şeşenoğlu Ö., AYDOĞAN F. , Çapanoğlu D., Neslihanoğlu R.

TETRAHEDRON-ASYMMETRY, cilt.12, ss.1953-1956, 2001 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 12 Konu: 13
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0957-4166(01)00346-9
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayısı: ss.1953-1956

Özet

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.