Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

Demir, AS; Hamamcı, Haluk; Şeşenoğlu, Özge; AYDOĞAN, Feray; Çapanoğlu, Doğa; Neslihanoğlu, Rahşan

doi:10.1016/s0957-4166(01)00346-9

Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

Demir A., Hamamcı H., Şeşenoğlu Ö., AYDOĞAN F., Çapanoğlu D., Neslihanoğlu R.

TETRAHEDRON-ASYMMETRY, cilt.12, sa.13, ss.1953-1956, 2001 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 13
Basım Tarihi: 2001
Doi Numarası: 10.1016/s0957-4166(01)00346-9
Dergi Adı: TETRAHEDRON-ASYMMETRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1953-1956
Yıldız Teknik Üniversitesi Adresli: Evet

Özet

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.