Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

Demir A., Hamamcı H., Şeşenoğlu Ö., AYDOĞAN F., Çapanoğlu D., Neslihanoğlu R.

TETRAHEDRON-ASYMMETRY, vol.12, no.13, pp.1953-1956, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 13
  • Publication Date: 2001
  • Doi Number: 10.1016/s0957-4166(01)00346-9
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1953-1956
  • Yıldız Technical University Affiliated: Yes


A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.