Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives


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PEKSEL A., Celik C., Ocal N., Yanardag R.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, vol.78, no.1, pp.15-25, 2013 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.2298/jsc120123036p
  • Journal Name: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.15-25
  • Keywords: norcantharidin, bridged perhydroisoindole, reducing power, super-oxide anion radical, 1,3-DIPOLAR CYCLOADDITION REACTION, SUBSTITUTED CYCLIC IMIDES, ANTICANCER, EXTRACTS

Abstract

A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies, such as total reducing power, 1,1-diphenyl-2-picryl-hydrazil (DPPH center dot) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among the 11 tested compounds, 7 compounds showed potent reducing power activity and 7 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds have effective antioxidant power.