Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, cilt.78, sa.1, ss.15-25, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 1
- Basım Tarihi: 2013
- Doi Numarası: 10.2298/jsc120123036p
- Dergi Adı: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.15-25
- Anahtar Kelimeler: norcantharidin, bridged perhydroisoindole, reducing power, super-oxide anion radical, 1,3-DIPOLAR CYCLOADDITION REACTION, SUBSTITUTED CYCLIC IMIDES, ANTICANCER, EXTRACTS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies, such as total reducing power, 1,1-diphenyl-2-picryl-hydrazil (DPPH center dot) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among the 11 tested compounds, 7 compounds showed potent reducing power activity and 7 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds have effective antioxidant power.