Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives

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PEKSEL A., Celik C., Ocal N., Yanardag R.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, cilt.78, sa.1, ss.15-25, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2298/jsc120123036p
  • Dergi Adı: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.15-25
  • Anahtar Kelimeler: norcantharidin, bridged perhydroisoindole, reducing power, super-oxide anion radical, 1,3-DIPOLAR CYCLOADDITION REACTION, SUBSTITUTED CYCLIC IMIDES, ANTICANCER, EXTRACTS
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies, such as total reducing power, 1,1-diphenyl-2-picryl-hydrazil (DPPH center dot) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among the 11 tested compounds, 7 compounds showed potent reducing power activity and 7 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds have effective antioxidant power.