Breast cancer prognosis in relation to family history of breast and ovarian cancer

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Thalib L., Wedrén S., Granath F., Adami H., Rydh B., Magnusson C., ...More

BRITISH JOURNAL OF CANCER, vol.90, no.7, pp.1378-1381, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 90 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1038/sj.bjc.6601694
  • Journal Name: BRITISH JOURNAL OF CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1378-1381
  • Yıldız Technical University Affiliated: No

Abstract

We linked four nationwide Swedish population-based registries to identify first-degree family history of breast and ovarian cancer among breast cancer cases diagnosed between 1991 and 1998 and followed them until death, emigration or end of follow-up in December 1998. The median follow-up was 36 months. Using Cox proportional hazards models, the hazard ratio of death (HR) due to breast cancer was estimated. Women with a family history of breast or ovarian cancer (n = 2175, 12.7%) had a nonsignificantly better prognosis than women without any family history, HR 0.86 (95% CI 0.71-1.05); this appeared unrelated to age at diagnosis either in the index case or in relative(s) with breast and/or ovarian cancer. Our study shows that prognostic outlook is not worse among breast cancer patients with family history.