Ibuprofen release from porous hydroxyapatite tablets

ÖNER M., Yetiz E., Ay E., Uysal U.

CERAMICS INTERNATIONAL, vol.37, no.7, pp.2117-2125, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.1016/j.ceramint.2011.02.021
  • Journal Name: CERAMICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2117-2125
  • Keywords: Biomedical applications, Hydroxyapatite, Drug release, Ibuprofen, CALCIUM-PHOSPHATE CEMENT, DRUG-DELIVERY SYSTEM, MIXING SOLUTION VOLUME, IN-VITRO, INDOMETHACIN RELEASE, TEMPERATURE, FABRICATION, MCM-41
  • Yıldız Technical University Affiliated: Yes

Abstract

The present study investigated drug release profiles from porous hydroxyapatite [Ca(5)(PO(4))(3)OH, HAP] tablets. HAP tablets prepared synthetically and porous structure was generated via microemulsion after sintering at 700 degrees C. The influence of tablet's microemulsion concentration on drug release profiles from sintered porous tablets was investigated by using ibuprofen (C(13)H(18)O(2)) as model drug.