Quality control of iodine-131-labeled metaiodobenzylguanidine


Tasdelen B., Kam E. , Asliyuksek H.

NUCLEAR MEDICINE COMMUNICATIONS, cilt.35, ss.95-98, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35 Konu: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1097/mnm.0000000000000016
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Sayfa Sayıları: ss.95-98

Özet

Aim/objectives/backgroundIodine-131-m-iodobenzylguanidine ([I-131]mIBG) is used worldwide for the diagnosis and therapy of neuroendocrine tumors, particularly adrenal medullae tumors. After the synthesis and preparation of a radioiodinated MIBG drug formulation, quality control testing to determine its radiochemical purity (RCP) should be performed. European Pharmacopoeia 8.0 requires that the quality control include a test for RCP for the determination of [I-131]mIBG. Previously reported procedures using reversed-phase conditions require long retention times. Our system enables the separation of [I-131]mIBG within a few minutes. The aim of this work was to carry out RCP testing for [I-131]mIBG without any type of sample pretreatment.MethodsRCP testing for [I-131]mIBG has been carried out using high-performance liquid chromatography and thin-layer chromatography methods.ResultsA simple and rapid reversed-phase isocratic system enables the HPLC investigation of RCP testing for [I-131]mIBG used for therapy within a few minutes.ConclusionsFrom the point of view of radiation protection, this method is safer, especially for therapeutic amounts of [I-131]mIBG.