Evaluation of natural gum-based cryogels for soft tissue engineering

Bektas E. I., GÜREL PEKÖZER G., Kök F. N., Torun Kose G.

Carbohydrate Polymers, vol.271, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 271
  • Publication Date: 2021
  • Doi Number: 10.1016/j.carbpol.2021.118407
  • Journal Name: Carbohydrate Polymers
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Locust bean gum, Xanthan gum, Mastic gum, Cryogels, Kartogenin, Soft tissue engineering, LOCUST BEAN GUM, XANTHAN GUM, MASTIC GUM, PORE-SIZE, IN-VITRO, CHONDROGENIC DIFFERENTIATION, MECHANICAL-PROPERTIES, GELATIN SCAFFOLD, HYDROGEL, DELIVERY
  • Yıldız Technical University Affiliated: Yes

Abstract

© 2021 Elsevier LtdIn this study, three natural biomaterials, Locust bean gum (LBG), Xanthan gum (XG), and Mastic gum (MG), were combined to form cryogel scaffolds. Thermal and chemical characterizations revealed the successful blend formation from LBG-XG (LX) and LBG-XG-MG (LXM) polymers. All blends resulted in macro-porous scaffolds with interconnected pore structures under the size of 400 μm. The swollen cryogels had similar mechanical properties compared with other polysaccharide-based cryogels. The mean tensile and compressive modulus values of the wet cryogels were in the range of 3.5–11.6 kPa and 82–398 kPa, respectively. The sustained release of the small molecule Kartogenin from varying concentrations and ratios of cryogels was in between 32 and 66% through 21 days of incubation. Physical, mechanical, and chemical properties make LX and LXM polysaccharide-based cryogels promising candidates for cartilage and other soft tissue engineering, and drug delivery applications.