Modeling particle size of polyacrylic acid-copper(II)-bovine serum albumin ternary complex in salt solution

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Şakar Daşdan D., Karahan M., Noyan Tekeli F., Gölbaşı Şimşek G.

Journal Of The Indian Chemical Society, vol.96, no.9, pp.1195-1198, 2019 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 9
  • Publication Date: 2019
  • Journal Name: Journal Of The Indian Chemical Society
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1195-1198
  • Yıldız Technical University Affiliated: Yes


Particle size and zeta potential of polyelectrolyte-protein binary conjugate and polyelectrolyte-metal-protein ternary complexes are among the most important factors affecting biopharmaceutical behavior such as bioavailability, dissolution and immune toxicity of these complexes. For this purpose, in the current study, the interactions between binary and ternary anionic polyelectrolyte, “polyacrylic acid (PAA)”, BSA and copper ions in different salt concentrations were investigated by zetasizer analysis. The particle size of poly(acrylic acid)-copper (II)-bovine serum albumin (BSA) ternary complex in a salt solution was modeled using extensive regression methods from Partial Least Squares (PLS) regression to conventional multiple linear regression.