Investigation of poly(ethylene-alt-maleic-anhydride)-pregabalin (1:1) ratio controlled drug delivery system synthesized in catalyst-free media: stability and activity at different pHs

Eslek O., Sakar D.

Bulgarian Chemical Communications, cilt.55, sa.3, ss.295-298, 2023 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.34049/bcc.55.3.ncntc11
  • Dergi Adı: Bulgarian Chemical Communications
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.295-298
  • Anahtar Kelimeler: activity, Controlled drug delivery system, poly(ethylene-alt-maleic-anhydride), pregabalin, stability
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

The controlled release of pregabalin drug active material covalently bound to poly(ethylene-alt-maleic anhydride) (PEAMA) copolymer was aimed in order to prevent the drug leaving the polymer matrix. Also, it was proposed to increase stability and activity of the drug, thus reducing frequent drug intake. Poly(ethylene-alt-maleic anhydride) (PEAMA) and pregabalin (PRG) at a (1:1) ratio copolymer-drug delitvery system (PEAMA-PRGI) was synthesized in catalyst-free media and was characterized by 1H NMR and FTIR/ATR. The stability and activity of PEAMA-PRGI copolymer-drug delivery system were determined in different pH environments at 37 oC via zetasizer measurements and UV/VIS spectroscopy, respectively.