Investigation of poly(ethylene-alt-maleic-anhydride)-pregabalin (1:1) ratio controlled drug delivery system synthesized in catalyst-free media: stability and activity at different pHs

Eslek O., Sakar D.

Bulgarian Chemical Communications, vol.55, no.3, pp.295-298, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.34049/bcc.55.3.ncntc11
  • Journal Name: Bulgarian Chemical Communications
  • Journal Indexes: Scopus
  • Page Numbers: pp.295-298
  • Keywords: activity, Controlled drug delivery system, poly(ethylene-alt-maleic-anhydride), pregabalin, stability
  • Yıldız Technical University Affiliated: Yes


The controlled release of pregabalin drug active material covalently bound to poly(ethylene-alt-maleic anhydride) (PEAMA) copolymer was aimed in order to prevent the drug leaving the polymer matrix. Also, it was proposed to increase stability and activity of the drug, thus reducing frequent drug intake. Poly(ethylene-alt-maleic anhydride) (PEAMA) and pregabalin (PRG) at a (1:1) ratio copolymer-drug delitvery system (PEAMA-PRGI) was synthesized in catalyst-free media and was characterized by 1H NMR and FTIR/ATR. The stability and activity of PEAMA-PRGI copolymer-drug delivery system were determined in different pH environments at 37 oC via zetasizer measurements and UV/VIS spectroscopy, respectively.