Alveolar-capillary adaptation to chronic hypoxia in the fatty lung

Yilmaz C. , RAVIKUMAR P., GYAWALI D., IYER R., UNGER R. H. , HSIA C. C. W.

ACTA PHYSIOLOGICA, cilt.213, sa.4, ss.933-946, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 213 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/apha.12419
  • Dergi Adı: ACTA PHYSIOLOGICA
  • Sayfa Sayıları: ss.933-946

Özet

Aim: Obese diabetic (ZDF fa/fa) rats with genetic leptin resistance suffer chronic lipotoxicity associated with age-related lung restriction and abnormal alveolar ultrastructure. We hypothesized that these abnormalities impair adaptation to ambient hypoxia.