Alveolar-capillary adaptation to chronic hypoxia in the fatty lung

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Yilmaz C. , RAVIKUMAR P., GYAWALI D., IYER R., UNGER R. H. , HSIA C. C. W.

ACTA PHYSIOLOGICA, vol.213, no.4, pp.933-946, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 213 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1111/apha.12419
  • Title of Journal : ACTA PHYSIOLOGICA
  • Page Numbers: pp.933-946

Abstract

Aim: Obese diabetic (ZDF fa/fa) rats with genetic leptin resistance suffer chronic lipotoxicity associated with age-related lung restriction and abnormal alveolar ultrastructure. We hypothesized that these abnormalities impair adaptation to ambient hypoxia.