Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

Gormez, Selcuk; Demirkan, Ayse; Atalar, Fatmahan; Caynak, Baris; Erdim, Refik; Sözer, Volkan; Gunay, Demet; Akpinar, Bellhan; Ozbek, Ugur; Buyukdevrim, Ahmet

doi:10.2169/internalmedicine.50.4753

Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

Gormez S., Demirkan A., Atalar F., Caynak B., Erdim R., Sözer V., ...Daha Fazla

INTERNAL MEDICINE, cilt.50, sa.8, ss.805-810, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 50 Sayı: 8
Basım Tarihi: 2011
Doi Numarası: 10.2169/internalmedicine.50.4753
Dergi Adı: INTERNAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.805-810
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.