Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

Gormez, Selcuk; Demirkan, Ayse; Atalar, Fatmahan; Caynak, Baris; Erdim, Refik; Sözer, Volkan; Gunay, Demet; Akpinar, Bellhan; Ozbek, Ugur; Buyukdevrim, Ahmet

doi:10.2169/internalmedicine.50.4753

Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

Gormez S., Demirkan A., Atalar F., Caynak B., Erdim R., Sözer V., ...More

INTERNAL MEDICINE, vol.50, no.8, pp.805-810, 2011 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 50 Issue: 8
Publication Date: 2011
Doi Number: 10.2169/internalmedicine.50.4753
Journal Name: INTERNAL MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.805-810
Open Archive Collection: AVESIS Open Access Collection
Yıldız Technical University Affiliated: Yes

Abstract

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.