Sentetik Antibakteriyel Polimerlerin Sentezi ve Bakteri Biyosensöründeki Uygulamaları


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Eren T.

16th European Workshop on Phosphorus Chemistry, Bristol, İngiltere, 24 Nisan - 26 Eylül 2019, ss.55

  • Basıldığı Şehir: Bristol
  • Basıldığı Ülke: İngiltere
  • Sayfa Sayısı: ss.55

Özet

Bacterial pathogens are the main cause of disease and death in human and veterinary medicine worldwide. The emergence of antibiotic resistant pathogens emphasizes the seriousness of this problem, particularly in the context of current issues related to biosecurity. Besides, microbial contamination against food and water is greatly damaging to production and economic safety.1 It has been reported that antimicrobial peptides (AMPs) adhere to bacteria without dissolving their cells. Based on this principle, many biosensors have been developed in recent years. The size and properties of nanoparticles make them perfect platforms for detection and identification of pathogens in natural biological samples.2

In our study, cationic copolymers which are more stable than AMPs derivatives were synthesized and then covalently attached to ironoxide nanoparticles (IONP) surface and bacterial sensor application was performed. 1H, 13C and 31P NMR, FTIR and TGA techniques were used for characterization of copolymers and IONP. For the antibacterial properties of the copolymers, a bacterial analysis test was performed on the surface. The copolymers were coated on interdigitated gold electrodes and applied for detection of the bacteria by using Electrochemical Impedance Spectroscopy.