The main objective of the present study is to evaluate the performance of the MIKE 21 SW (Spectral Wave) in a semi-closed basin (Black Sea). Wind data were obtained from the European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-Interim, ECMWF ERA5, and the National Centers for Environmental Prediction (NCEP) Climate Forecast System Reanalysis (CFSR) datasets. The wave model was calibrated and validated with wave measurements recorded at seven different stations along the Black Sea coastlines. During the calibration, several different physical parameters were tested to determine the optimal model settings, with the whitecapping parameter (Cds) being more influential than the bottom friction parameter (kn), wave breaking parameter (γ), and nonlinear wave-wave interactions in the prediction of the Black Sea wave properties. The wave results modeled using ERA-Interim showed less agreement with wave measurements than those obtained with ERA-5 and CFSR wind fields. Although the significant wave height and wave period modeled using ERA5 and CFSR wind fields were reasonably well matched at all measurement stations, ERA5 wind fields provided slightly better performance owing to having the largest correlation coefficient (R) and lowest statistical error measures (bias, RMSE, SI) in the Black Sea.