Development of a Potential Multilayered Biofunctional Dressing for Localized Postoperative Cancer Treatment: A Hybrid Approach Using 3D Printing and Electrospinning
Macromolecular Materials and Engineering, cilt.310, sa.11, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 310 Sayı: 11
- Basım Tarihi: 2025
- Doi Numarası: 10.1002/mame.202500218
- Dergi Adı: Macromolecular Materials and Engineering
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC, Directory of Open Access Journals
- Anahtar Kelimeler: electrospraying, multiphase release system, tissue engineering, triple-drug release, tumor dressing
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
This study introduces a multilayered biofunctional tumor dressing designed for localized treatment after tumor resection. The system incorporates three therapeutic agents: doxorubicin (DOX) for anticancer action, amoxicillin (AMOX) for antibacterial protection, and ibuprofen (IBU) for anti-inflammatory support. These drugs were loaded into polyvinyl alcohol (PVA) and polycaprolactone (PCL) matrices via a hybrid method combining 3D printing, electrospinning, and electrospraying. FTIR, SEM, and optical microscopy confirmed structural integrity. in vitro release at pH 7.4 and 37°C showed rapid DOX and AMOX release within 240 min, while IBU exhibited sustained release over 120 h. Mathematical modeling (zero-order, first-order, Higuchi, and Korsmeyer–Peppas) indicated diffusion-driven, matrix-controlled kinetics. Encapsulation efficiencies exceeded 98%, affirming fabrication reliability. Antibacterial tests showed stronger activity against Staphylococcus aureus than Escherichia coli. Cytotoxicity results demonstrated selective toxicity, with 42.86% viability in CCD1072-Sk fibroblasts and lower survival in MCF-7 (25.63%) and A549 (23.76%) cancer cells. This multifunctional dressing enables spatial and temporal control over drug release to effectively manage residual tumor cells, infection, and inflammation, offering a promising strategy for postoperative cancer therapy with minimized systemic side effects.