Reactions of 1,4-dianion of methyl 2-thienyl ketone N-ethoxycarbonylhydrazone with derivatives of carboxylic acids, and the synthesis of pyrazolotriazin-7-ones

Turgut Z., Ocal N.

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol.38, no.4, pp.602-605, 2002 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.1023/a:1016571828025
  • Journal Name: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.602-605
  • Yıldız Technical University Affiliated: Yes

Abstract

1,3,5-trisubstituted pyrazoles were obtained by reaction of carboxylic acids derivatives with 1,4-dianion of methyl 2-thienyl ketone N-ethoxycarbonylhydrazone. The dianion was prepared by treating the hydrazone with butyllithium in THF at -78degreesC. Besides were prepared 4-methyl (or 4-phenyl)-2-(2-thienyl)-6H-pyrazolo [1,5-d][1,2,4]triazin-7-ones from the corresponding 1,3,5-trisubstituted pyrazoles synthesized respectively, with the use of ethyl pyruvate and ethyl phenylglyoxylate.