Non-enzymatic glucose biosensor based on overoxidized polypyrrole nanofiber electrode modified with cobalt(II) phthalocyanine tetrasulfonate


Ozcan L., ŞAHİN Y. , Turk H.

BIOSENSORS & BIOELECTRONICS, vol.24, no.4, pp.512-517, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1016/j.bios.2008.05.004
  • Title of Journal : BIOSENSORS & BIOELECTRONICS
  • Page Numbers: pp.512-517
  • Keywords: Overoxidized polypyrrole, Biosensor, Cobalt(II) phthalocyanine, Glucose, Electrocatalysis, PENCIL GRAPHITE ELECTRODE, GLASSY-CARBON ELECTRODE, ELECTROCATALYTIC OXIDATION, AMPEROMETRIC SENSOR, ELECTROCHEMICAL DETECTION, CONDUCTING POLYMER, OXIDASE, FILM, ELECTROOXIDATION, NITRITE

Abstract

An enzymeless biosensor, based on electrode position of overoxidized polypyrrole nanofiber onto pencil graphite electrode and modified with cobalt(II) phthalocyanine tetrasulfonate (CoPcTS), was investigated in this study. CoPcTS showed electrocatalytic activity for the oxidation of glucose in alkaline solution. The electrochemical performance of the modified electrodes was investigated by differential pulse voltammetric (DPV) method. The resulting biosensor exhibited excellent performance for glucose determination with a wide linear range (0.25-20 mM), a highly reproducible response (R.S.D. of 2.7%), low percentage of the interferences and long-term stability. The calculated detection limit was 0.1 mM at 3 sigma. in order to verify the reliability of the biosensor, it was applied to the determination of glucose in serum samples. The results were satisfactory and agreed closely with those measured in a hospital. (C) 2008 Elsevier B.V. All rights reserved.