Non-enzymatic glucose biosensor based on overoxidized polypyrrole nanofiber electrode modified with cobalt(II) phthalocyanine tetrasulfonate

Ozcan L., ŞAHİN Y., Turk H.

BIOSENSORS & BIOELECTRONICS, cilt.24, sa.4, ss.512-517, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.bios.2008.05.004
  • Dergi Adı: BIOSENSORS & BIOELECTRONICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.512-517
  • Anahtar Kelimeler: Overoxidized polypyrrole, Biosensor, Cobalt(II) phthalocyanine, Glucose, Electrocatalysis, PENCIL GRAPHITE ELECTRODE, GLASSY-CARBON ELECTRODE, ELECTROCATALYTIC OXIDATION, AMPEROMETRIC SENSOR, ELECTROCHEMICAL DETECTION, CONDUCTING POLYMER, OXIDASE, FILM, ELECTROOXIDATION, NITRITE
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

An enzymeless biosensor, based on electrode position of overoxidized polypyrrole nanofiber onto pencil graphite electrode and modified with cobalt(II) phthalocyanine tetrasulfonate (CoPcTS), was investigated in this study. CoPcTS showed electrocatalytic activity for the oxidation of glucose in alkaline solution. The electrochemical performance of the modified electrodes was investigated by differential pulse voltammetric (DPV) method. The resulting biosensor exhibited excellent performance for glucose determination with a wide linear range (0.25-20 mM), a highly reproducible response (R.S.D. of 2.7%), low percentage of the interferences and long-term stability. The calculated detection limit was 0.1 mM at 3 sigma. in order to verify the reliability of the biosensor, it was applied to the determination of glucose in serum samples. The results were satisfactory and agreed closely with those measured in a hospital. (C) 2008 Elsevier B.V. All rights reserved.