New and effective proline-based catalysts for asymmetric aldol reaction in water


Yorulmaz T., Aydoğan F. , Yolaçan Ç.

SYNTHETIC COMMUNICATIONS, vol.47, pp.78-85, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47
  • Publication Date: 2017
  • Doi Number: 10.1080/00397911.2016.1252988
  • Journal Name: SYNTHETIC COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.78-85

Abstract

New proline diamide organocatalysts with Pro-Phe peptide bonds were synthesized and their catalytic activities in asymmetric direct aldol reactions of aliphatic ketones with aromatic aldehydes were investigated. Catalyst 6a showed good enantioselectivity at 0 degrees C in the presence of p-nitrobenzoic acid as cocatalyst in water.