New and effective proline-based catalysts for asymmetric aldol reaction in water
SYNTHETIC COMMUNICATIONS, vol.47, pp.78-85, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 47
- Publication Date: 2017
- Doi Number: 10.1080/00397911.2016.1252988
- Journal Name: SYNTHETIC COMMUNICATIONS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.78-85
- Yıldız Technical University Affiliated: Yes
Abstract
New proline diamide organocatalysts with Pro-Phe peptide bonds were synthesized and their catalytic activities in asymmetric direct aldol reactions of aliphatic ketones with aromatic aldehydes were investigated. Catalyst 6a showed good enantioselectivity at 0 degrees C in the presence of p-nitrobenzoic acid as cocatalyst in water.