New and effective proline-based catalysts for asymmetric aldol reaction in water


YORULMAZ T., AYDOĞAN F. , YOLAÇAN Ç.

SYNTHETIC COMMUNICATIONS, cilt.47, ss.78-85, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 47 Konu: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/00397911.2016.1252988
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Sayfa Sayıları: ss.78-85

Özet

New proline diamide organocatalysts with Pro-Phe peptide bonds were synthesized and their catalytic activities in asymmetric direct aldol reactions of aliphatic ketones with aromatic aldehydes were investigated. Catalyst 6a showed good enantioselectivity at 0 degrees C in the presence of p-nitrobenzoic acid as cocatalyst in water.