Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plantGeigeria alata(DC) Oliv. & Hiern.


Fadul E., Nizamani A., Rasheed S., Adhikari A., Yousuf S., Parveen S., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.34, sa.17, ss.2456-2464, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Konu: 17
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/14786419.2018.1542388
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Sayfa Sayıları: ss.2456-2464

Özet

A new sesquiterpene lactone geigerianoloide (1) and four known flavonoids axillarin (2), quercetin (3), 3-methoxy-5,7,3',4'-tetrahydroxy-flavone (4) and hispidulin (5) were isolated fromGeigeria alata(DC) Oliv. & Hiern. (Asteraceae). Structures were deduced using(1)H- and(13)C- NMR spectroscopy, mass spectrometry, while the structure of compound1was also deduced using X-ray crystallography technique. Geigeria alatais traditionally used for diabetes, therefore compounds were tested for anti-glycation activity, in which compounds2and3showed potent activities (IC(50)values of 246.97 +/- 0.83 and 262.37 +/- 0.22 mu M, respectively) compared to IC(50)value 294.50 +/- 1.5 mu M of rutin. Moreover, compound4exhibited a comparable activity to rutin (IC50 = 293.28 +/- 1.34 mu M). Compound5showed a weak activity. Compounds2,3, and4exhibited potent DPPH radical scavenging activity (IC50 = 0.1 +/- 0.00, 0.13 +/- 0.00 and 0.15 +/- 0.01 mu M, respectively). Compounds2,3, and4demonstrated significant superoxide anion scavenging activity with IC(50)values of 0.14 +/- 0.001, 0.17 +/- 0.00, and 0.11 +/- 0.006 mu M, respectively.