Akademik Veri Yönetim Sistemi
Bulgarian Chemical Communications, cilt.55, sa.3, ss.289-294, 2023 (Scopus)
Polysaccharide-based materials are derived from plants and can be blended with other bioactive materials to enhance their properties, resulting in improved drug release, stability, bioavailability, and target specificity. Polysaccharides are known to exhibit delayed color development, reduced acidity, and increased firmness in drug materials. Therefore, it is necessary to study the mechanisms underlying their kinetics to understand their high activities, potencies, and specificities when used in pharmaceutical products. The present study aims to investigate the potential of various polysaccharides as transdermal films to control the release of donepezil hydrochloride, a drug commonly used to treat Alzheimer's disease. For this purpose, pectin and guar gum were used as a polysaccharide-based polymer matrix for the transdermal films. The drug release kinetics was determined by analyzing samples taken at various time intervals using a UV spectrophotometer. In vitro, drug release studies were performed for donepezil hydrochloride by using a Franz diffusion cell which simulates human skin. To investigate release kinetics, data obtained from in-vitro drug release studies were plotted in various kinetic models which include zero order, first order, Higuchi and Korsmeyer-Peppas. The results in the present work confirm the controlled release of donepezil hydrochloride and the polysaccharide content of the transdermal patch can extend the release of donepezil hydrochloride. Therefore, the study's results suggest that pectin and guar gum have potential as new materials for developing treatments for Alzheimer's disease and other diseases that require continuous drug release.